Selank

Selank 5mg Overview

Selank is a synthetic heptapeptide categorized as a regulatory peptide with significant neurobiological activity. It is a derivative of the tetrapeptide Tuftsin, modified with additional amino acids to ensure metabolic persistence. This 5mg research preparation is designed for investigators studying the complex interactions between neurochemistry and immune function.

As a research compound, Selank is studied for its ability to regulate serotonin and dopamine metabolism, as well as its interaction with the GABAergic system. It is provided in a stable, lyophilized form for long-term laboratory utility.

• Formulation: 5mg Lyophilized Solid
• Safety Note: Strictly for laboratory research. Not approved for human or veterinary use.

Selank Structure

The structure of Selank is specifically engineered to improve upon the half-life of natural Tuftsin while maintaining its biological efficacy.

• Sequence: Thr-Lys-Pro-Arg-Pro-Gly-Pro
• Structure Solution Formula: Carbon 33 Hydrogen 57 Nitrogen 11 Oxygen 9
• Molecular Formula: C33H57N11O9
• Molecular Weight: 751.87 g/mol
• CAS Number: 129954-34-3

Analysis Type

Specification

Purity

99 percent minimum

Solubility

Distilled Water, DMSO

Molecular Weight

751.87

Sequence

Heptapeptide

Selank Research

Research data on Selank indicates a multifaceted approach to treating neurological imbalances in laboratory settings.

Anxiolytic Efficacy

In comparative studies with traditional benzodiazepines, Selank has shown similar efficacy in reducing anxiety markers in rat models. However, it does not produce the characteristic side effects of memory impairment or sedation. This makes it an ideal subject for research into non-habit-forming anxiolytics.

Gene Expression and Memory

Selank has the unique ability to influence the mRNA expression of several dozen genes within the hippocampus. This includes genes related to neurotransmitter receptors and ion-dependent signaling. By altering gene expression, Selank strengthens the stability of memory traces and enhances cognitive performance under stressful conditions.

Stress and Enkephalinase

Research into the biochemical mechanisms of Selank shows that it inhibits the breakdown of enkephalins in the bloodstream. By increasing the presence of these natural peptides, Selank acts as a buffer against the negative impacts of chronic stress on the brain.

Selank and the Immune System in Anxiety

Selank's role in immunomodulation is centered on its ability to regulate cytokine levels. Studies in patients with depression and anxiety disorders indicate that Selank can normalize IL-6 levels, which are often elevated during periods of chronic stress.

In animal models, Selank has been shown to affect the expression of the Bcl6 gene, which is essential for immune system development. This suggests that Selank’s neuroprotective effects are inextricably linked to its ability to manage systemic inflammation.

Article Author

The literature reviewed in this profile was authored and compiled by Dr. Ivan P. Ashmarin, Ph.D. Dr. Ashmarin was the head of the Department of Human and Animal Physiology at Moscow State University and a primary architect in the field of peptide research.

Scientific Journal Author

The findings reported in this product description are based on peer-reviewed research by Dr. Ivan P. Ashmarin and his collaborators, including A.E. Medvedev and L.S. Inozemtseva. Their collective work on the monoamine system and peptide stability forms the scientific backbone of current Selank research.

Reference Citations

1. Ashmarin IP, et al. Tuftsin analogs in neuropeptide research: Selank development. Neurochem J. 2008;2(3):173–180.
2. Andreeva LA, et al. Selank's anxiolytic effect compared to benzodiazepines. Bull Exp Biol Med. 2008;145(3):347-350.
3. Medvedev AE, et al. Selank and modulation of GABAergic activity. Neurochem Res. 2017;42(10):2801-2808.
4. Kopeikina E, et al. Selank-induced BDNF expression and neuroprotection. Neurochem Int. 2019;128:21-27.
5. Dolotov OV, et al. Selank modulation of serotonin metabolism. Neurosci Lett. 2018;678:79-84.
6. Kovaleva ES, et al. Selank's immunomodulatory and antiviral activity. Dokl Biochem Biophys. 2012;443:72-76.
7. Inozemtseva LS, et al. Neuroprotective effects of Selank in experimental models. Bull Exp Biol Med. 2017;162(4):455–459.
8. Kudrin VS, et al. Impact of Selank on monoamine metabolism. Neurochem J. 2010;4(1):39-45.
9. Semenova TP, et al. Selank improves memory and cognitive function in animal studies. Bull Exp Biol Med. 2015;159(5):640-643.
10. Kolesnikova TO, et al. Pharmacokinetics of Selank in rodent models. Pharm Chem J. 2009;43:295-299.

Storage

Storage Instructions

Proper storage is paramount for maintaining the integrity of the peptide sequence. Selank is provided in a lyophilized powder form, which is stable for transport but highly sensitive to temperature once reconstituted.

• Lyophilized Storage: Store at -20 degrees Celsius. Keep away from light and moisture.
• Reconstituted Storage: Must be kept in a refrigerator at 2 to 8 degrees Celsius. Use within 4 weeks of mixing.

Best Practices For Storing Peptides

Always use sterile, non-pyrogenic water for reconstitution. To avoid contamination, ensure the rubber stopper is sanitized before and after each use. Store vials in an airtight container to prevent oxidation.